Working alongside AWS, the company identified an opportunity to enhance this experiment by using BioNeMo. This dramatically improved candidate quality, thus progressing promising drug candidates more efficiently through the wet lab with fewer design-build-test cycles required.
Reported impact
A-Alpha Bio is now poised to adopt BioNeMo as its standard solution for future campaigns. It plans to explore additional foundation models in BioNeMo, such as ESM-3 and OpenFold for protein folding. Key reported metrics include faster inference calls 12x; 12x; more protein-binding predictions evaluated 10x.
Learn how biotechnology company A-Alpha Bio scaled protein-binding predictions by 10 times while increasing model speed by 12 times using BioNeMo on AWS. Biotechnology startup A-Alpha Bio specializes in harnessing synthetic biology and machine learning (ML) to measure, predict, and engineer protein-protein interactions (PPIs). The company used BioNeMo Framework—a generative artificial intelligence (AI) solution for drug discovery from NVIDIA , an AWS Partner —on Amazon Web Services (AWS) compute infrastructure. Using BioNeMo on AWS, A-Alpha Bio achieved a 12-times increase in throughput of PPI binding predictions, processing over 100 million inference calls—10 times what it had initially projected—in 2 months. A-Alpha Bio conducted training on AWS, supported by a straightforward and efficient setup process. Source data enters the A-Alpha Bio workflow through its application services, processed with Amazon EC2 Capacity Blocks for ML, Amazon EC2 P5 Instances.
Source data enters the A-Alpha Bio workflow through its application services, processed with Amazon EC2 Capacity Blocks for ML, Amazon EC2 P5 Instances.
10x
12x
1–2
A-Alpha Bio’s pioneering work in therapeutic development centers around the discovery and optimization of protein sequences that meet specific design criteria for designing monoclonal antibodies (mABs).
It plans to explore additional foundation models in BioNeMo, such as ESM-3 and OpenFold for protein folding.
Working alongside AWS, the company identified an opportunity to enhance this experiment by using BioNeMo. This dramatically improved candidate quality, thus progressing promising drug candidates more efficiently through the wet lab with few
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The company says A-Alpha Bio is based in Seattle.
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